Ctrl & F - Attack & Talk With Npcs.
Left Click - Target a player or NPC
Right Click - On players: show interactive drop down menu, On monsters/tiles: Send pet to attack/move
Tab - Rage Attack & (also functions as Attack).
Space - Picks up items you're standing on
R - Changes targeting to your closest Party Member.
I - Opens Inventory.
E - Opens Spell Book.
Q - Opens Quest Log.
C - Opens Character Sheet and Equipped Items Page.
O - Opens Options.
P - Opens the Pet Menu.
G - Guild menu.
WASD- Movement keys (Up, Left, Down, Right, respectively)
Shift+Alt+Click - Brings you to Wiki page of quest/item/NPC clicked on
Chat Channels (F keys)
F1 - "Broadcast" nicknamed Global, messages sent here are visible to anyone on your current server. Requires Combat Level 5.
F2 - "Map" messages sent here will be visible to anyone on the same map as yourself, it also produces a chat box above your characters head, displaying the message.
F3 - "Emote" this channel does not have a function currently.
F4 - "Party" this chat reaches only the individuals you are in a party with you. This chat shows as purple in color for everyone.
F5 - "Guild" this channel sends message to all guild members currently on your server.
/who - This command tells you how many players are online and all of their names.
/fps - This command will put your "FPS" (Frames per second) and "Ping" (connection speed) on the right hand side of your screen.
/fpslock - This command will lock your frames (can reduce lag)
/bugreport - You can use this function to report a bug within the game.
/removeblock name - Removes block for specified character.